MedfordRecruiter Since 2001
the smart solution for Medford jobs

Director, DMPK

Company: HireMinds
Location: Talent
Posted on: February 25, 2021

Job Description:

Get notified when the right job is available Our growing Small Molecule client in Watertown, MA is growing and looking to bring on board a Sr. Director, DMPK to join the Preclinical Development team! The ideal candidate will partner with project teams to set forth strategic DMPK paths to advance projects from early discovery through clinical development. The ability to work effectively in a collaborative, interdisciplinary team environment is essential to this role with the expectation that this scientist will interact with all disciplines of drug development, including medicinal chemistry, biology, formulation, translational medicine, and regulatory. Experience in small molecule drug discovery and deep understanding in the key ADME processes or PK/PD modeling is required. Responsibilities:

  • Serve as the DMPK representative to ensure effective application and integration of ADME, PK, and PK/PD studies in support of discovery and development programs
  • Identify critical ADME/PK needs and propose strategies
  • Design and oversee DMPK studies, review and summarize results, integrate ADME, PK, and PK/PD information to guide multi-disciplinary team efforts in lead optimization and to facilitate selection of development candidates.
  • Deliver and communicate results to project teams, provide intellectual input, and contribute to decision making.
  • Collaborate with other functions such as biology and translational medicine to define PK-PD relationships in preclinical pharmacology studies and in clinic.
  • Write and review relevant sections of regulatory documents.
  • Manage interactions with external CROs to ensure high quality and on-time execution of DMPK studies.
  • Identify and qualify external vendors for ADME/PK, Tox, and BA support of research programs.
  • Design study, review study protocol, study results, and finalize reports.
  • Maintain complete and timely data archiving.
  • Coordinate operational logistics among in-house functions and external vendors. Requirements
    • Master or PhD in drug metabolism, Pharmacokinetics, Pharmaceutical Sciences, Pharmacology, or related disciplines with 15+ years (with MSc) / 5 - 10 years (with PhD) of relevant experience in the pharmaceutical industry or CROs.
    • In-depth understanding and strategic application of most in vitro and in vivo ADME assays, methods and models. Ability to gather most relevant information to facilitate human PK and dose projection.
    • Direct hands-on experience and strong trouble shooting skills in most in vitro and vivo DMPK studies, including PK and PK/PD analysis, quantitative and qualitative LC-MS analysis, in vitro and in vivo biotransformation, and human PK and drug interaction predictions.
    • Expertise in managing CROs and sound knowledge of regulatory guidelines on DDIs, bioanalysis, and GLP practice.
    • Proficiency in Phoenix WinNonlin (classic WNL and PHX Model). Ability to develop user-specified mathematical models highly desired. Familiarity with R and NONMEM a plus.
    • Strong analytical, organizational, and communication skills.

Keywords: HireMinds, Medford , Director, DMPK, Executive , Talent, Oregon

Click here to apply!

Didn't find what you're looking for? Search again!

I'm looking for
in category
within


Other Executive Jobs


Salon Manager - East Grants Pass
Description: Salon ManagerGot shears and a winning attitude Have a yearning to earn and a desire to hire and support other stylists Then let's talk Maybe you're a stylist who wants more responsibility,
Company: Great Clips
Location: Rogue River
Posted on: 03/8/2021

Salon Manager - Central Point
Description: Salon ManagerGot shears and a winning attitude Have a yearning to earn and a desire to hire and support other stylists Then let's talk Maybe you're a stylist who wants more responsibility,
Company: Great Clips
Location: Central Point
Posted on: 03/8/2021

Salon Manager
Description: Job Description Got shears and a winning attitude Have a yearning to earn and a desire to hire
Company: Great Clips
Location: Grants Pass
Posted on: 03/7/2021


Health Services Director - Registered Nurse - Relocation Provided to Corvallis, OR
Description: Questions Contact Director of Talent Acquisition Blake Thiess at 360.600.9285 or at bthiess prestigecare.com.:: What does the Health Services Director do The Health Services Director oversees the health (more...)
Company: Prestige Care, Inc.
Location: Phoenix
Posted on: 03/7/2021

Assistant Salon Manager - Mid-town Medford
Description: Assistant Salon ManagerGot shears and a winning attitude Have a yearning to earn and a desire to support other stylists Then let s talk Maybe you re a stylist who wants more
Company: Great Clips
Location: Rogue River
Posted on: 03/8/2021

Regional Sales Manager - Own a Franchise
Description: Own A Franchise br 40 BUSINESS CATEGORIES br PROVEN BUSINESS MODELS br FIND OUT HOW BUSINESS br OWNERS CAN EARN MORE br Have you ever thought about owning your own business If so, now is the (more...)
Company: Franchise Career Advisor
Location: Klamath Falls
Posted on: 03/8/2021

Assistant Salon Manager - West Grants Pass
Description: Assistant Salon ManagerGot shears and a winning attitude Have a yearning to earn and a desire to support other stylists Then let's talk Maybe you're a stylist who wants more responsibility,
Company: Great Clips
Location: Gold Hill
Posted on: 03/8/2021

Manager, Customer Support
Description: The Role:As the Manager of the Customer Support, you will be responsible for leading our Customer Support team, who provides quality and timely service to educational institutions, administrators, teachers, (more...)
Company: Newsela
Location: Myrtle Point
Posted on: 03/7/2021

Salon Manager - Klamath Falls
Description: Salon ManagerGot shears and a winning attitude Have a yearning to earn and a desire to hire and support other stylists Then let's talk Maybe you're a stylist who wants more responsibility,
Company: Great Clips
Location: Klamath Falls
Posted on: 03/8/2021

Assistant Salon Manager - South Medford
Description: Assistant Salon ManagerGot shears and a winning attitude Have a yearning to earn and a desire to support other stylists Then let's talk Maybe you're a stylist who wants more responsibility,
Company: Great Clips
Location: Central Point
Posted on: 03/8/2021

Log In or Create An Account

Get the latest Oregon jobs by following @recnetOR on Twitter!

Medford RSS job feeds